Tirzepatide for maintenance of body weight reduction in people with obesity
Horn DB et al, Lancet. 2026;407(10545):2305-2318
This phase 3 trial (SURMOUNT-MAINTAIN) compared the impact of tirzepatide therapy with a maximum tolerated dose, 5 mg and placebo, respectively, on the maintenance of body weight reduction. Long term treatment was often necessary to maintain body weight reduction. Dose reduction to 5 mg tirzepatide may be a valuable alternative to discontinuation, but responses vary.
Background: Obesity treatment improves long-term health and quality of life outcomes. Weight reduction and its maintenance play an important role in achieving these goals. We evaluated the efficacy and safety of continuing tirzepatide at the maximum tolerated dose (MTD) or lowering the dose to 5 mg compared with switching to placebo on the maintenance of body weight reduction obtained with tirzepatide MTD in adults with obesity.
Methods: This phase 3b, placebo-controlled, 112-week trial, including a 60-week open-label weight-loss period and a 52-week, double-blind weight maintenance period, was conducted across 20 sites in the USA. After completing the initial weight-loss period with once weekly subcutaneous tirzepatide at the MTD (10 mg or 15 mg), adults (aged ≥ 18 years) with a BMI of 30 kg/m2 and above or 27 kg/m2 and above with one or more weight-related comorbidity, and a history of at least one self-reported unsuccessful dietary effort to lose body weight were randomly assigned in a 3:3:2 ratio to continue tirzepatide MTD, reduce to tirzepatide 5 mg, or switch to placebo for an additional 52 weeks. Starting at week 84 (24 weeks after random allocation), participants could receive rescue tirzepatide if their weight regain exceeded 50%. The primary endpoint was the percentage change in body weight from baseline to week 112. The primary estimand was the modified treatment-regimen estimand, which assumed that participants who initiated rescue tirzepatide would not have gained further benefit from their assigned study treatment and included all randomly allocated participants, regardless of treatment discontinuation or initiation of prohibited medications. The efficacy estimand was supportive. Safety was assessed in all participants who received at least one dose of study drug.
Findings: From September 20, 2023, to January 20, 2026, 441 patients were enrolled in and took at least one dose of study treatment during the weight-loss period, with 378 participants randomly allocated at week 60 (140 to tirzepatide MTD; 144 to dose-reduction to 5 mg tirzepatide; and 94 to placebo). 372 received at least one dose of study drug during the weight maintenance period (139 for tirzepatide MTD; 142 for 5 mg tirzepatide; and 91 for placebo). 345 (91%) of 378 participants completed the study. The majority of participants were White (67%); 288 (65%) participants were female and 153 (35%) were male; and the mean age was 46.6 years (SD 13.0). At baseline, participants had a mean body weight of 113.8 kg (SD 27.0), a BMI of 40.1 kg/m2 (SD 8.1), and HbA1c 5.64% (SD 0.4; 38.2 mmol/mol [SD 4.0]). The model-based estimate percent change in body weight from baseline to week 112 was -21.9% (95% CI: -23.5 to -20.3) with MTD (estimated treatment difference [ETD] -12.0% [95% CI: -13s.8 to -10.1]), -16.6% (95% CI: -18.0 to -15.1) with 5 mg tirzepatide (ETD -6.6 [95% CI: -8.3 to -5.0]), versus -9.9% (95% CI: -11.1 to -8.8) with placebo (p < 0.0001 for all comparisons). Among participants who regained at least 50% of lost body weight, observed means were 11 (8%) of 138, 35 (25%) of 142, and 60 (67%) of 90 participants received rescue therapy in the tirzepatide MTD, 5 mg tirzepatide, and placebo, respectively. The most common adverse events with tirzepatide were gastrointestinal events, which were mostly mild to moderate in severity and mostly occurred during dose escalation.
Interpretation: In adults with obesity, long-term treatment is often necessary to maintain body weight reduction and its associated cardiometabolic benefits. In the SURMOUNT-MAINTAIN trial, continuing tirzepatide at MTD maintained body weight reduction and health-related benefits. Reducing to 5 mg tirzepatide might provide a valuable alternative to discontinuation, although individuals' treatment response might vary. Together, these findings support the importance of ongoing therapy for long-term obesity management and provide evidence to inform individualised, patient-centred obesity care.