Long-term effects of colonoscopy screening vs. no screening on colorectal cancer incidence – the NORDICC trial revisited
Kaminski MF et al, Lancet. 2026;407(10541):1787-1795
Follow-up analysis of the NORDICC trial suggests that one colonoscopy significantly reduces colorectal cancer incidence but not mortality after 13 years. However, colorectal cancer mortality in both groups was lower than anticipated.
Background: We previously reported the 10-year effects of colonoscopy screening on colorectal cancer incidence and mortality. Here, we report the effects after 13 years of follow-up.
Methods: In this multicountry, population-based randomised controlled trial, 84,583 men and women aged 55-64 years at enrolment from Norway, Poland, and Sweden were randomly allocated (1:2) to colonoscopy screening or no screening and analysed. The primary outcomes were colorectal cancer incidence and mortality after 10-15 years of follow-up in intention-to-screen analyses, with first analysis after 10 years, and repeated every other year or at longer intervals.
Findings: At 13 years of follow-up, colorectal cancer incidence was 375 colorectal cancers (1.46%) of 28,217 individuals in the screening group and 912 colorectal cancers (1.80%) of 56 366 individuals in the no-screening group. The risk ratio (RR) was 0.81 (95% CI: 0.71-0.90) in intention-to-screen analyses and 0.55 (0.33-0.81) in per-protocol analyses. The risk for proximal colorectal cancer was 129 (0.51%) in the screening group versus 283 (0.56%) in the no-screening group (RR = 0.91 [0.71-1.09]), and the risk for distal colorectal cancer was 224 (0.87%) in the screening group versus 563 (1.11%) in the no-screening group (RR = 0.79 [0.65-0.89]; interaction p < 0.0001). In men, the colorectal cancer risk was 214 (1.69%) of 14,154 in the screening group and 541 (2.19%) of 28,247 in the no-screening group (RR = 0.77 [0.64 to -0.88]); in women, the risk was 161 (1.24%) of 14,063 in the screening group versus 371 (1.43%) of 28 119 in the no-screening group (RR = 0.87 [0.70-1.02]; interaction p < 0.0001). Colorectal cancer mortality was 106 (0.41%) of 28,217 in the screening group and 236 (0.47%) of 56,366 in the no-screening group (intention-to-screen RR = 0.88 [0.68-1.08], per-protocol RR = 0.70 [0.26-1.25]). The observed colorectal cancer mortality in the non-screening group (0.47%) was substantially lower than expected at the time of designing the trial (0.82%).
Interpretation: One colonoscopy significantly reduced colorectal cancer incidence but not mortality over 13 years. Colorectal cancer mortality was lower in both study groups than when the trial was designed.